Evaluation and Management of Testosterone Deficiency: AUA Guideline.

Autor:	Mulhall JP; American Urological Association Education and Research, Inc., Linthicum, Maryland., Trost LW; American Urological Association Education and Research, Inc., Linthicum, Maryland., Brannigan RE; American Urological Association Education and Research, Inc., Linthicum, Maryland., Kurtz EG; American Urological Association Education and Research, Inc., Linthicum, Maryland., Redmon JB; American Urological Association Education and Research, Inc., Linthicum, Maryland., Chiles KA; American Urological Association Education and Research, Inc., Linthicum, Maryland., Lightner DJ; American Urological Association Education and Research, Inc., Linthicum, Maryland., Miner MM; American Urological Association Education and Research, Inc., Linthicum, Maryland., Murad MH; American Urological Association Education and Research, Inc., Linthicum, Maryland., Nelson CJ; American Urological Association Education and Research, Inc., Linthicum, Maryland., Platz EA; American Urological Association Education and Research, Inc., Linthicum, Maryland., Ramanathan LV; American Urological Association Education and Research, Inc., Linthicum, Maryland., Lewis RW; American Urological Association Education and Research, Inc., Linthicum, Maryland.
Jazyk:	angličtina
Zdroj:	The Journal of urology [J Urol] 2018 Aug; Vol. 200 (2), pp. 423-432. Date of Electronic Publication: 2018 Mar 28.
DOI:	10.1016/j.juro.2018.03.115
Abstrakt:	Purpose: There has been a marked increase in testosterone prescriptions in the past decade resulting in a growing need to give practicing clinicians proper guidance on the evaluation and management of the testosterone deficient patient. Materials and Methods: A systematic review utilized research from the Mayo Clinic Evidence Based Practice Center and additional supplementation by the authors. Evidence-based statements were based on body of evidence strength Grade A, B, or C and were designated as Strong, Moderate, and Conditional Recommendations with additional statements presented in the form of Clinical Principles or Expert Opinions (table 1 in supplementary unabridged guideline, http://jurology.com/). Results: This guideline was developed by a multi-disciplinary panel to inform clinicians on the proper assessment of patients with testosterone deficiency and the safe and effective management of men on testosterone therapy. Additional statements were developed to guide the clinician on the appropriate care of patients who are at risk for or have cardiovascular disease or prostate cancer as well as patients who are interested in preserving fertility. Conclusions: The care of testosterone deficient patients should focus on accurate assessment of total testosterone levels, symptoms, and signs as well as proper on-treatment monitoring to ensure therapeutic testosterone levels are reached and symptoms are ameliorated. Future longitudinal observational studies and clinical trials of significant duration in this space will improve diagnostic techniques and treatment of men with testosterone deficiency as well as provide more data on the adverse events that may be associated with testosterone therapy. (Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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