Re-Examination of the Esophageal Squamous Cell Carcinoma Model in Rats Induced by N-Nitrososarcosine Ethyl Ester Precursors.

Autor: Shubin AV; Institute of Molecular Genetics, the Russian Academy of Sciences, Moscow, Russia., Lesovaya EA; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia., Kirsanov KI; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia., Antoshina EE; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia., Trukhanova LS; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia., Gorkova TG; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia., Belitsky GA; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia., Yakubovskaya MG; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, Moscow, Russia., Demidyuk IV; Institute of Molecular Genetics, the Russian Academy of Sciences, Moscow, Russia. duk@img.ras.ru.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Mar; Vol. 164 (5), pp. 676-679. Date of Electronic Publication: 2018 Mar 26.
DOI: 10.1007/s10517-018-4057-2
Abstrakt: Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these models is esophageal cancer induction in rats by N-nitroso compound precursors. Despite adequate reproduction of human esophageal cancer, this model in fact has not been used since the 1990ies. Re-examination of esophageal cancer model, induced by N-nitrososarcosine ethyl ester precursors, is carried out and its efficiency in induction of squamous cell carcinoma is confirmed.
Databáze: MEDLINE
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