Pre-operative quantification of pulmonary function using hybrid-SPECT/low-dose-CT: A pilot study.

Autor: Genseke P; Department for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany. Electronic address: philipp.genseke@med.ovgu.de., Wetz C; Department for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany; Department of Nuclear Medicine, Charité University Hospital Berlin, Berlin, Germany., Wallbaum T; Department for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Kreissl MC; Department for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Ghazzawi S; Department for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Schreiber J; Department for Pneumology, University Hospital Magdeburg, Magdeburg, Germany., Amthauer H; Department of Nuclear Medicine, Charité University Hospital Berlin, Berlin, Germany., Grosser OS; Department for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany.
Jazyk: angličtina
Zdroj: Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2018 Apr; Vol. 118, pp. 155-160. Date of Electronic Publication: 2018 Feb 19.
DOI: 10.1016/j.lungcan.2018.02.010
Abstrakt: Rationale: Pre-operative lobar function is estimated by scintigraphy in patients with pulmonary malignancies and compromised function. This study compared the lobar perfusion determined by scintigraphy (PS) with data from SPECT/low-dose-CT (SPECT/ldCT) analyzed manually and semi-automatic.
Methods: Retrospective analysis on 39 patients (m/f = 25/14; age: 72.5 [22-89] years) with indication for pulmonary perfusion scintigraphy. Imaging was performed using SPECT/ldCT. Data was analyzed manually and by semi-automatic software. Readers' confidence in 3D-segmentation was scored by two independent readers. Interrater agreement was calculated. In addition, Spearman's rank correlation and Wilcoxon's test were used.
Results: Results from PS differed significantly from SPECT/ldCT processed manually or semi-automatically in 4/5 lobes (total difference ≤21.6%; rho ≥0.44) and in 3/5 (total difference 21.6%; rho ≥0.37), respectively. Readers' confidence in 3D-segmentation showed a perfect interrater agreement (κ = 0.98).
Conclusion: Quantification of lobar perfusion by SPECT/ldCT differs significantly from planar scintigraphy (e.g., with potential influence on therapy). The semi-automatic software analysis provides an applicable methodology.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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