Physical characterization and in vivo organ distribution of coated iron oxide nanoparticles.

Autor: Sharma A; Johns Hopkins University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, 1550 Orleans Street, CRB II, Baltimore, MD, 21231, USA., Cornejo C; Johns Hopkins University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, 1550 Orleans Street, CRB II, Baltimore, MD, 21231, USA., Mihalic J; Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD, 21205, USA., Geyh A; Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD, 21205, USA., Bordelon DE; Johns Hopkins University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, 1550 Orleans Street, CRB II, Baltimore, MD, 21231, USA., Korangath P; Johns Hopkins University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, 1550 Orleans Street, CRB II, Baltimore, MD, 21231, USA., Westphal F; Micromod Partikeltechnologie GmbH, Friedrich-Barnewitz-St 4, D-18119, Rostock, Germany., Gruettner C; Micromod Partikeltechnologie GmbH, Friedrich-Barnewitz-St 4, D-18119, Rostock, Germany., Ivkov R; Johns Hopkins University School of Medicine, Department of Radiation Oncology and Molecular Radiation Sciences, 1550 Orleans Street, CRB II, Baltimore, MD, 21231, USA. rivkov1@jhmi.edu.; Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, 21218 USA, USA. rivkov1@jhmi.edu.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Centre, School of Medicine, Johns Hopkins University, Baltimore, MD, 21231, USA. rivkov1@jhmi.edu.; Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, 21218, USA. rivkov1@jhmi.edu.; Institute for NanoBioTechnology, Whiting School of Engineering, Johns Hopkins University, Baltimore, 21218, USA. rivkov1@jhmi.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2018 Mar 20; Vol. 8 (1), pp. 4916. Date of Electronic Publication: 2018 Mar 20.
DOI: 10.1038/s41598-018-23317-2
Abstrakt: Citrate-stabilized iron oxide magnetic nanoparticles (MNPs) were coated with one of carboxymethyl dextran (CM-dextran), polyethylene glycol-polyethylene imine (PEG-PEI), methoxy-PEG-phosphate+rutin, or dextran. They were characterized for size, zeta potential, hysteresis heating in an alternating magnetic field, dynamic magnetic susceptibility, and examined for their distribution in mouse organs following intravenous delivery. Except for PEG-PEI-coated nanoparticles, all coated nanoparticles had a negative zeta potential at physiological pH. Nanoparticle sizing by dynamic light scattering revealed an increased nanoparticle hydrodynamic diameter upon coating. Magnetic hysteresis heating changed little with coating; however, the larger particles demonstrated significant shifts of the peak of complex magnetic susceptibility to lower frequency. 48 hours following intravenous injection of nanoparticles, mice were sacrificed and tissues were collected to measure iron concentration. Iron deposition from nanoparticles possessing a negative surface potential was observed to have highest accumulation in livers and spleens. In contrast, iron deposition from positively charged PEG-PEI-coated nanoparticles was observed to have highest concentration in lungs. These preliminary results suggest a complex interplay between nanoparticle size and charge determines organ distribution of systemically-delivered iron oxide magnetic nanoparticles.
Databáze: MEDLINE
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