Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain.

Autor: Román M; Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain., Caicoya M; Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain., Espinàs J; Department of Health, Catalan Cancer Plan, Barcelona, Spain., Sala M; Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain., Torá-Rocamora I; Preventive Medicine and Epidemiology Department, Hospital Clinic, Barcelona, Spain., Quinta MJ; Epidemiology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Vernet M; Department of Obstetrics and Gynecology, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Saladié F; Breast Cancer Screening Program of Tarragona, The Foundation League for the Research and Prevention of Cancer, Tarragona, Spain., Romero A; Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain., Sánchez M; General Directorate of Public Health, Government of Cantabria, Santander, Spain., Baré M; Clinical Epidemiology and Cancer Screening, Parc Taulí University Hospital, Sabadell, Spain., Vidal C; Cancer Prevention and Monitoring Program, Catalan Institute of Oncology, Barcelona, Spain., Servitja S; Department of Oncology, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Natal C; Breast Cancer Screening Program, Principality of Asturias, Oviedo, Spain., Corominas J; Department of Pathological Anatomy, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Ferrer J; Radiology Department, Hospital de Santa Caterina, Girona, Spain., Rodríguez-Arana A; Department of Image Diagnostics, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Castells X; Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain.
Jazyk: angličtina
Zdroj: The breast journal [Breast J] 2018 Jul; Vol. 24 (4), pp. 509-518. Date of Electronic Publication: 2018 Mar 08.
DOI: 10.1111/tbj.13003
Abstrakt: Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69 years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03-2.08), metastatic positive (OR = 2.66; 95%CI = 1.21-5.86), and with a high Ki-67 proliferation rate (OR = 1.93; 95%CI = 1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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