Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death.

Autor:	Galimov ER; Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK., Pryor RE; Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK., Poole SE; Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK., Benedetto A; Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK; Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YW, UK., Pincus Z; Department of Genetics and Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO 63110, USA., Gems D; Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, UK. Electronic address: david.gems@ucl.ac.uk.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2018 Mar 06; Vol. 22 (10), pp. 2730-2741.
DOI:	10.1016/j.celrep.2018.02.050
Abstrakt:	Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca 2+ release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca 2+ influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. VIDEO ABSTRACT. (Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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