Molecular coordination of Staphylococcus aureus cell division.

Autor:	Lund VA; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom., Wacnik K; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom., Turner RD; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.; Department of Physics and Astronomy, University of Sheffield, Sheffield, United Kingdom., Cotterell BE; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.; Department of Chemistry, University of Sheffield, Sheffield, United Kingdom., Walther CG; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom., Fenn SJ; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom., Grein F; Institute for Pharmaceutical Microbiology, German Center for Infection Research (DZIF), University of Bonn, Bonn, Germany., Wollman AJ; Biological Physical Sciences Institute, University of York, York, United Kingdom., Leake MC; Biological Physical Sciences Institute, University of York, York, United Kingdom., Olivier N; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Physics and Astronomy, University of Sheffield, Sheffield, United Kingdom., Cadby A; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Physics and Astronomy, University of Sheffield, Sheffield, United Kingdom., Mesnage S; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom., Jones S; Department of Chemistry, University of Sheffield, Sheffield, United Kingdom., Foster SJ; Krebs Institute, University of Sheffield, Sheffield, United Kingdom.; Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2018 Feb 21; Vol. 7. Date of Electronic Publication: 2018 Feb 21.
DOI:	10.7554/eLife.32057
Abstrakt:	The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen Staphylococcus aureus is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components. Competing Interests: VL, KW, RT, BC, CW, SF, FG, AW, ML, NO, AC, SM, SJ, SF No competing interests declared (© 2018, Lund et al.)
Databáze:	MEDLINE
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