Effect of scaling and root planing on levels of 8-hydroxydeoxyguanosine in gingival crevicular fluid of chronic periodontitis patients with and without Type II diabetes mellitus.

Autor:	Muthuraj MSA; Department of Periodontics and Implantology, Sri Ramakrishna Dental College, Coimbatore, Tamil Nadu, India., Janakiram S; Department of Periodontics and Implantology, Sri Ramakrishna Dental College, Coimbatore, Tamil Nadu, India., Chithresan K; Department of Periodontics and Implantology, Sri Ramakrishna Dental College, Coimbatore, Tamil Nadu, India., Maradi AP; Department of Periodontics and Implantology, Sri Ramakrishna Dental College, Coimbatore, Tamil Nadu, India., Maddur PK; Department of Periodontics and Implantology, Sri Ramakrishna Dental College, Coimbatore, Tamil Nadu, India., Rangaraju R; Department of Periodontics and Implantology, Sri Ramakrishna Dental College, Coimbatore, Tamil Nadu, India.
Jazyk:	angličtina
Zdroj:	Journal of Indian Society of Periodontology [J Indian Soc Periodontol] 2017 May-Jun; Vol. 21 (3), pp. 201-206.
DOI:	10.4103/jisp.jisp_184_17
Abstrakt:	Context: Chronic periodontitis (CP) and diabetes mellitus are associated with increased oxidative damage to DNA with formation of 8-hydroxydeoxyguanosine (8-OHdG). The aim of this study was to evaluate the change in gingival crevicular fluid (GCF) levels of 8-OHdG and glycosylated hemoglobin (HbA1c) by 3 months after scaling and root planing (SRP), in CP patients with and without Type II diabetes mellitus. Settings and Design: Sixteen patients with CP, 16 patients with CP and Type II diabetes mellitus (CP-D), and 16 systemically healthy individuals with clinically healthy periodontium who served as controls were included in the study. Materials and Methods: The clinical parameters (plaque index [PI], probing depth [PD], clinical attachment level [CAL], and bleeding on probing [BOP%]), HbA1c levels, and GCF 8-OHdG levels were measured at baseline. All the patients except controls were treated with SRP followed by evaluation of the above-mentioned clinical and biochemical parameters after 3 months. Statistical Analysis Used: Statistical analysis was performed using paired t -test, independent t -test, and Mann-Whitney U-test. Results: After SRP, CP-D group showed a greater reduction in PI, PD, BOP%, and greater gain in CAL when compared to CP patients ( P < 0.05). Levels of 8-OHdG and HbA1c in CP-D patients also showed a greater reduction, 3 months after SRP when compared to CP patients ( P < 0.05). Conclusions: GCF 8-OHdG levels, HbA1c levels, and clinical parameters were reduced significantly in CP and CP-D patients, with maximum reduction achieved in CP-D patients 3 months after SRP. Competing Interests: There are no conflicts of interest.
Databáze:	MEDLINE
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