The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall.
| Autor: | Ghequire MGK; Centre of Microbial and Plant Genetics, KU Leuven, Heverlee, Belgium maarten.ghequire@kuleuven.be., Buchanan SK; Laboratory of Molecular Biology, National Institute of Diabetes and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA., De Mot R; Centre of Microbial and Plant Genetics, KU Leuven, Heverlee, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | MBio [mBio] 2018 Feb 13; Vol. 9 (1). Date of Electronic Publication: 2018 Feb 13. |
| DOI: | 10.1128/mBio.02267-17 |
| Abstrakt: | Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a catalytic domain (ColM) targeting lipid II. Diversifying recombination has enabled parasitism of different receptors and has also given rise to hybrid bacteriocins in which ColM is associated with another toxin module. Remarkably, ColM toxins have recruited a diverse array of immunity partners, comprising cytoplasmic membrane-associated proteins with different topologies. Together, these findings suggest that different immunity mechanisms have evolved for ColM, in contrast to bacteriocins with nuclease activities. (Copyright © 2018 Ghequire et al.) |
| Databáze: | MEDLINE |
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