Depiction of pneumothoraces in a large animal model using x-ray dark-field radiography.

Autor:	Hellbach K; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany. katharina.hellbach@med.uni-muenchen.de., Baehr A; Chair for Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-University Munich, Munich, 85764, Oberschleißheim, Germany., De Marco F; Chair of Biomedical Physics & Munich School of BioEngineering, Technical University of Munich, Munich, 85748, Garching, Germany., Willer K; Chair of Biomedical Physics & Munich School of BioEngineering, Technical University of Munich, Munich, 85748, Garching, Germany., Gromann LB; Chair of Biomedical Physics & Munich School of BioEngineering, Technical University of Munich, Munich, 85748, Garching, Germany., Herzen J; Chair of Biomedical Physics & Munich School of BioEngineering, Technical University of Munich, Munich, 85748, Garching, Germany., Dmochewitz M; Chair for Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-University Munich, Munich, 85764, Oberschleißheim, Germany., Auweter S; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany., Fingerle AA; Department of Diagnostic and Interventional Radiology, Technical University of Munich, 81675, Munich, Germany., Noël PB; Chair of Biomedical Physics & Munich School of BioEngineering, Technical University of Munich, Munich, 85748, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, 81675, Munich, Germany., Rummeny EJ; Department of Diagnostic and Interventional Radiology, Technical University of Munich, 81675, Munich, Germany., Yaroshenko A; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Maack HI; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Pralow T; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., van der Heijden H; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Wieberneit N; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Proksa R; Philips GmbH Innovative Technologies, Research Laboratories, 22335, Hamburg, Germany., Koehler T; Philips GmbH Innovative Technologies, Research Laboratories, 22335, Hamburg, Germany.; Institute for Advanced Study, Technical University of Munich, 85748, Garching, Germany., Rindt K; Philips Medical Systems DMC GmbH, 22335, Hamburg, Germany., Schroeter TJ; Institute of Microstructure Technology, Karlsruhe Institute of Technology (KIT), 76344, Eggenstein-Leopoldshafen, Germany., Mohr J; Institute of Microstructure Technology, Karlsruhe Institute of Technology (KIT), 76344, Eggenstein-Leopoldshafen, Germany., Bamberg F; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center (CPC-M), Helmholtz Zentrum Munich, 81377, Munich, Germany., Ertl-Wagner B; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center (CPC-M), Helmholtz Zentrum Munich, 81377, Munich, Germany., Pfeiffer F; Chair of Biomedical Physics & Munich School of BioEngineering, Technical University of Munich, Munich, 85748, Garching, Germany.; Department of Diagnostic and Interventional Radiology, Technical University of Munich, 81675, Munich, Germany.; Institute for Advanced Study, Technical University of Munich, 85748, Garching, Germany., Reiser MF; Department of Radiology, University Hospital, LMU Munich, 81377, Munich, Germany.; German Center for Lung Research (DZL), Comprehensive Pneumology Center (CPC-M), Helmholtz Zentrum Munich, 81377, Munich, Germany.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2018 Feb 08; Vol. 8 (1), pp. 2602. Date of Electronic Publication: 2018 Feb 08.
DOI:	10.1038/s41598-018-20985-y
Abstrakt:	The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-to-noise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 ± 0.9) than in the transmission images (1.13 ± 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.
Databáze:	MEDLINE
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