IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy, and atopic dermatitis.

Autor: Heeringa JJ; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Rijvers L; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Arends NJ; Department of Allergy, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., Driessen GJ; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Haga Teaching Hospital, Juliana Children's Hospital, The Hague, The Netherlands., Pasmans SG; Department of Pediatric Dermatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., van Dongen JJM; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., de Jongste JC; Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands., van Zelm MC; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.; Department of Immunology and Pathology, Central Clinical School, Monash University and Alfred Hospital, Melbourne, VIC, Australia.
Jazyk: angličtina
Zdroj: Allergy [Allergy] 2018 Jun; Vol. 73 (6), pp. 1331-1336. Date of Electronic Publication: 2018 Mar 30.
DOI: 10.1111/all.13421
Abstrakt: Despite the critical role of soluble IgE in the pathology of IgE-mediated allergic disease, little is known about abnormalities in the memory B cells and plasma cells that produce IgE in allergic patients. We here applied a flow cytometric approach to cross-sectionally study blood IgE+ memory B cells and plasmablasts in 149 children with atopic dermatitis, food allergy, and/or asthma and correlated these to helper T(h)2 cells and eosinophils. Children with allergic disease had increased numbers of IgE+CD27- and IgE+CD27+ memory B cells and IgE+ plasmablasts, as well as increased numbers of eosinophils and Th2 cells. IgE+ plasmablast numbers correlated positively with Th2 cell numbers. These findings open new possibilities for diagnosis and monitoring of treatment in patients with allergic diseases.
(© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)
Databáze: MEDLINE
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