Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity.

Autor: Sperl MFJ; Department of Psychology, Personality Psychology and Assessment, University of Marburg, Marburg, Germany.; Department of Psychology, Clinical Psychology and Psychotherapy, University of Giessen, Giessen, Germany.; Department of Psychiatry, Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Panitz C; Department of Psychology, Personality Psychology and Assessment, University of Marburg, Marburg, Germany.; Department of Psychology, Clinical Psychology and Psychotherapy, University of Giessen, Giessen, Germany., Rosso IM; Department of Psychiatry, Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Dillon DG; Department of Psychiatry, Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Kumar P; Department of Psychiatry, Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Hermann A; Department of Psychology, Clinical Psychology and Psychotherapy, University of Giessen, Giessen, Germany., Whitton AE; Department of Psychiatry, Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Hermann C; Department of Psychology, Clinical Psychology and Psychotherapy, University of Giessen, Giessen, Germany., Pizzagalli DA; Department of Psychiatry, Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA., Mueller EM; Department of Psychology, Personality Psychology and Assessment, University of Marburg, Marburg, Germany.; Department of Psychology, Clinical Psychology and Psychotherapy, University of Giessen, Giessen, Germany.
Jazyk: angličtina
Zdroj: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2019 Feb 01; Vol. 29 (2), pp. 701-715.
DOI: 10.1093/cercor/bhx353
Abstrakt: Human functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) studies, as well as animal studies, indicate that the amygdala and frontomedial brain regions are critically involved in conditioned fear and that frontomedial oscillations in the theta range (4-8 Hz) may support communication between these brain regions. However, few studies have used a multimodal approach to probe interactions among these key regions in humans. Here, our goal was to bridge the gap between prior human fMRI, EEG, and animal findings. Using simultaneous EEG-fMRI recordings 24 h after fear conditioning and extinction, conditioned stimuli presented (CS+E, CS-E) and not presented during extinction (CS+N, CS-N) were compared to identify effects specific to extinction versus fear recall. Differential (CS+ vs. CS-) electrodermal, frontomedial theta (EEG) and amygdala responses (fMRI) were reduced for extinguished versus nonextinguished stimuli. Importantly, effects on theta power covaried with effects on amygdala activation. Fear and extinction recall as indicated by theta explained 60% of the variance for the analogous effect in the right amygdala. Our findings show for the first time the interplay of amygdala and frontomedial theta activity during fear and extinction recall in humans and provide insight into neural circuits consistently linked with top-down amygdala modulation in rodents.
Databáze: MEDLINE
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