Treatment with low doses of aspirin during chronic phase of experimental Chagas' disease increases oesophageal nitrergic neuronal subpopulation in mice.

Autor: Massocatto CL; University Center Integrado, Campo Mourão, Paraná, Brazil., Martins Moreira N; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., Muniz E; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., Marques de Araújo S; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil., Pinge-Filho P; Department of Pathological Sciences, State University of Londrina, Londrina, Paraná, Brazil., Rossi RM; Department of Statistics, State University of Maringá, Maringá, Paraná, Brazil., de Almeida Araújo EJ; Department of Histology, State University of Londrina, Londrina, Paraná, Brazil., de Mello Gonçales Sant'ana D; Department of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.
Jazyk: angličtina
Zdroj: International journal of experimental pathology [Int J Exp Pathol] 2017 Dec; Vol. 98 (6), pp. 356-362. Date of Electronic Publication: 2018 Jan 19.
DOI: 10.1111/iep.12259
Abstrakt: Patients with Chagas' disease may develop dysfunctions of oesophageal and colonic motility resulting from the degeneration or loss of the myenteric neurons of the enteric nervous system. Studies have shown that the use of aspirin, also known as acetylsalicylic acid (ASA), influences the pathogenesis of the disease. However, this remains controversial. The aim of this study was to evaluate the consequences of treatment with low doses of aspirin during the chronic phase of Chagas' disease on oesophageal function. Twenty male Swiss mice, 60 days of age, were used. The animals were infected with Y strain of Trypanosoma cruzi, injected intraperitoneally. Aspirin was given at a dose of 50 mg/kg to some of the infected animals, from the 55th to 63rd day after inoculation on consecutive days, and from the 65th to 75th day on alternate days. We investigated food passage of time, wall structure and nitrergic neuronal population of the distal oesophagus. Our data revealed that the use of low doses of aspirin in chronic Chagas' disease caused an increase in the number of nitrergic neurons and partially prevented hypertrophy of the oesophagus. In addition, the aspirin administration impeded Chagas' diseases associated changes in intestinal transit time. Thus treatment with aspirin in the chronic phase of Chagas' disease changes the natural history of the disease and raises the possibility of using it as a new therapeutic approach to the treatment of this aspect of Chagas' disease pathology.
(© 2018 The Authors. International Journal of Experimental Pathology © 2018 International Journal of Experimental Pathology.)
Databáze: MEDLINE
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