Are liver nested stromal epithelial tumors always low aggressive?

Autor:	Meletani T; Medical Oncology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Cantini L; Medical Oncology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Lanese A; Medical Oncology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Nicolini D; Hepatobiliary and Transplantation Surgery, Department of Clinical and Experimental Medicine, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Cimadamore A; Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Agostini A; Department of Radiology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Ricci G; Medical Oncology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Antognoli S; Medical Oncology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Mandolesi A; Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Guido M; Pathology Department, Padova University, 35121 Padova, Italy., Alaggio R; Pathology Department, Padova University, 35121 Padova, Italy., Giuseppetti GM; Department of Radiology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Scarpelli M; Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Vivarelli M; Hepatobiliary and Transplantation Surgery, Department of Clinical and Experimental Medicine, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy., Berardi R; Medical Oncology, University Hospital and Polytechnic University Ancona, 60126 Marche, Italy. r.berardi@univpm.it.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2017 Dec 14; Vol. 23 (46), pp. 8248-8255.
DOI:	10.3748/wjg.v23.i46.8248
Abstrakt:	Nested stromal-epithelial tumor (NSET) is a non-hepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calcification and ossification, which represents a very rare and challenging disease. Most of the reported cases have been treated with surgery, obtaining a long survival outcome. Here, we report the case of a 31-year-old Caucasian man who underwent surgery at our institution for a large, lobulated, multinodular mass of the right hemi-liver. The histological exam confirmed the diagnosis of NSET. After 6 mo from surgery, a liver recurrence was described and a chemo-embolization was performed. After a further disease progression, based on the correlation between the histological features of the disease and those of the hepatoblastoma, a similar chemotherapy regimen (with cisplatin and ifosfamide/mesna chemotherapy, omitting doxorubicin due to liver impairment) was administered. However, infection of the biliary catheter required a dose modification of the treatment. No benefit was noted and a progression of disease was radiologically assessed after only four cycles. The worsening of the clinical status prevented further treatments, and the patient died a few months later. This case report documents how the NSET might have an aggressive and non-preventable behavior. No chemotherapy schedules with a proved efficacy are available, and new data are needed to shed light on this rare neoplasm. Competing Interests: Conflict-of-interest statement: All authors declare having no conflicting interest.
Databáze:	MEDLINE
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