Phytochemical and pharmacological investigation of Spiraea chamaedryfolia: a contribution to the chemotaxonomy of Spiraea genus.

Autor: Kiss T; Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary.; Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary., Cank KB; Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary., Orbán-Gyapai O; Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary., Liktor-Busa E; Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary., Zomborszki ZP; Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary.; Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary., Rutkovska S; Department of Chemistry and Geography, Daugavpils University, Parādes st. 1, Daugavpils, 5401, Latvia., Pučka I; Department of Chemistry and Geography, Daugavpils University, Parādes st. 1, Daugavpils, 5401, Latvia., Németh A; Botanical Garden, University of Szeged, Lövölde u. 42, Szeged, 6726, Hungary., Csupor D; Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary. csupor.dezso@pharm.u-szeged.hu.; Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary. csupor.dezso@pharm.u-szeged.hu.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2017 Dec 21; Vol. 10 (1), pp. 762. Date of Electronic Publication: 2017 Dec 21.
DOI: 10.1186/s13104-017-3013-y
Abstrakt: Objective: Diterpene alkaloids are secondary plant metabolites and chemotaxonomical markers with a strong biological activity. These compounds are characteristic for the Ranunculaceae family, while their occurrence in other taxa is rare. Several species of the Spiraea genus (Rosaceae) are examples of this rarity. Screening Spiraea species for alkaloid content is a chemotaxonomical approach to clarify the classification and phylogeny of the genus. Novel pharmacological findings make further investigations of Spiraea diterpene alkaloids promising.
Results: Seven Spiraea species were screened for diterpene alkaloids. Phytochemical and pharmacological investigations were performed on Spiraea chamaedryfolia, the species found to contain diterpene alkaloids. Its alkaloid-rich fractions were found to exert a remarkable xanthine-oxidase inhibitory activity and a moderate antibacterial activity. The alkaloid distribution within the root was clarified by microscopic techniques.
Databáze: MEDLINE
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