Breaking the mold: structures of the RNA polymerase I transcription complex reveal a new path for initiation.
| Autor: | Jackobel AJ; a SUNY Upstate Medical University , Department of Biochemistry and Molecular Biology , 750 East Adams Street, Syracuse , NY 13210., Han Y; b Northwestern University , Department of Molecular Biosciences , 2205 Tech Drive, Evanston , IL 60208., He Y; b Northwestern University , Department of Molecular Biosciences , 2205 Tech Drive, Evanston , IL 60208., Knutson BA; a SUNY Upstate Medical University , Department of Biochemistry and Molecular Biology , 750 East Adams Street, Syracuse , NY 13210. |
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| Jazyk: | angličtina |
| Zdroj: | Transcription [Transcription] 2018; Vol. 9 (4), pp. 255-261. Date of Electronic Publication: 2018 Jan 15. |
| DOI: | 10.1080/21541264.2017.1416268 |
| Abstrakt: | While structures of the RNA polymerase (Pol) II initiation complex have been resolved and extensively studied, the Pol I initiation complex remained elusive. Here, we review the recent structural analyses of the yeast Pol I transcription initiation complex that reveal several unique and unexpected Pol I-specific properties. |
| Databáze: | MEDLINE |
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