Inhibitory effect of cranberry extract on periodontopathogenic biofilm: An integrative review.

Autor:	de Medeiros AKB; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., de Melo LA; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Alves RAH; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Barbosa GAS; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., de Lima KC; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil., Porto Carreiro ADF; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of Indian Society of Periodontology [J Indian Soc Periodontol] 2016 Sep-Oct; Vol. 20 (5), pp. 503-508.
DOI:	10.4103/jisp.jisp_302_16
Abstrakt:	Background: Combating biofilm-dependent oral infections involves the use of synthetic antibiotics, which are often associated with bacterial resistance and adverse effects. As a result, herbs such as cranberry have emerged as an alternative treatment. The aim of this study was to evaluate, through an integrative literature review, the effectiveness of cranberry extract on cultures and biofilms of periodontopathogenic bacteria. Materials and Methods: In vitro and in vivo studies evaluating the action of cranberry extract on the growth, coaggregation and formation of periodontopathogenic bacteria and periodontal biofilm were identified. Searches were carried out in the "Cochrane Library," "MEDLINE," "Web of Science," "Scopus," "LILACS," "Scielo," and "Google Scholar" databases, using the terms: "vaccinium macrocarpon;" "cranberries;" "cranberry;" "biofilms;" "periodontitis;" "chronic periodontitis;" "aggressive periodontitis;" "periodontal diseases;" and "periodont*." Results: a low number of studies evaluating the effectiveness of cranberry extract on periodontal disease were found, and no human studies were identified. In general, the eight studies included in the revision found that the compounds effectively inhibited the formation of a biofilm of Porphyromonas gingivalis and Fusobacterium nucleatum at concentrations equal or superior to 62.5 μg/ml, but did not significantly inhibit bacterial growth or promote the breakdown of preformed biofilm. Conclusions: while most of the studies presented certain methodological limitations, they did identify an inhibiting effect of cranberry on periodontal bacteria. These results serve as support for the development of further studies evaluating the most effective vehicle and ideal concentration that can be used without causing adverse effects on oral tissues. Competing Interests: There are no conflicts of interest.
Databáze:	MEDLINE
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