The Lipid Lowering and Cardioprotective Effects of Vernonia calvoana Ethanol Extract in Acetaminophen-Treated Rats.

Autor:	Egbung GE; Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540 Nigeria. eneji.egbung@unical.edu.ng., Atangwho IJ; Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540 Nigeria. dratangwho@gmail.com., Odey OD; Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540 Nigeria. diianer12@yahoo.com., Ndiodimma VN; Department of Biochemistry, University of Calabar, P.M.B 1115, Calabar 540 Nigeria. ndiodimmavictor@gmail.com.
Jazyk:	angličtina
Zdroj:	Medicines (Basel, Switzerland) [Medicines (Basel)] 2017 Dec 12; Vol. 4 (4). Date of Electronic Publication: 2017 Dec 12.
DOI:	10.3390/medicines4040090
Abstrakt:	Background: Paracetamol overdose/abuse as a result of self-medication is a common occurrence amongst people living in low/middle income countries. The present study was designed to investigate the hypolipidemic and cardioprotective potentials of Vernonia calvoana (VC) ethanol extract in acetaminophen (paracetamol)-treated rats. Methods: Thirty-five Wistar rats weighing 100-150 g were randomly assigned into five groups of seven rats each. Groups 2-5 received high doses of paracetamol to induce liver damage, while group 1 was used as normal control. Afterwards, they were allowed to receive varying doses of VC (group 3 and 4) or vitamin E (group 5), whilst groups 1 and 2 were left untreated. The treatment period lasted for twenty one days after which sera were harvested and assayed for serum lipid indices using standard methods. Results: Groups 3 to 5 treated animals indicated significant decrease ( p < 0.001) in low density lipoprotein cholesterol (LDL-c), total cholesterol (TC) and triacylglycerol (TG) levels relative to the normal and acetaminophen-treated controls, the atherogenic index showed a significant decrease ( p < 0.001) in all treated groups compared with normal and acetaminophen-treated controls. However, the VC- and vitamin E-treated groups showed significant ( p < 0.001) increase in high density lipoprotein cholesterol (HDL-C) relative to the controls. Conclusions: Data from our study suggest that ethanol leaf extract of VC possesses probable hypolipidemic and cardioprotective effects. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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