Phytochemical portfolio and anticancer activity of Murraya koenigii and its primary active component, mahanine.

Autor: Samanta SK; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India. Electronic address: suman_samanta699@yahoo.co.in., Kandimalla R; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India., Gogoi B; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India., Dutta KN; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India., Choudhury P; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India., Deb PK; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India., Devi R; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India., Pal BC; National Institute of Pharmaceutical Education and Research, Jadavpur, Kolkata, 700032, West Bengal, India., Talukdar NC; Life Science Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati, 781035, Assam, India. Electronic address: nctalukdar@yahoo.com.
Jazyk: angličtina
Zdroj: Pharmacological research [Pharmacol Res] 2018 Mar; Vol. 129, pp. 227-236. Date of Electronic Publication: 2017 Nov 23.
DOI: 10.1016/j.phrs.2017.11.024
Abstrakt: Murraya koenigii, a plant belonging to the Rutaceae family is widely distributed in Eastern-Asia and its medicinal properties are well documented in Ayurveda, the traditional Indian system of medicine. Through systematic research and pharmacological evaluation of different parts of the plant extracts has been shown to possess antiviral, anti-inflammatory, antioxidant, antidiabetic, antidiarrhoeal, antileishmanial, and antitumor activity. In the plant extracts, carbazole alkaloid, mahanine has been identified as the principle bioactive component among several other chemical constituents. Scientific evidence derived not only from in vitro cellular experiments but also from in vivo studies in various cancer models is accumulating for the pronounced anticancer effects of mahanine. The primary objective of this review is to summarize research data on cytotoxic chemical constituents present in different parts of Murraya koenigii and the anticancer activity of mahanine along with the recent understanding on the mechanism of its action in diverse cancer models. The information on its bioavailability and the toxicity generated from the recent studies have also been incorporated in the review.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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