In vitro percutaneous absorption and metabolism of Bisphenol A (BPA) through fresh human skin.

Autor: Toner F; Charles River Laboratories Edinburgh Ltd., UK., Allan G; Charles River Laboratories Edinburgh Ltd., UK., Dimond SS; Saudi Basic Industries Corporation - SABIC, Pittsfield, MA, USA., Waechter JM Jr; Consultant to SABIC, Traverse City, MI, USA., Beyer D; Bayer AG (on behalf of COVESTRO), Wuppertal, Germany. Electronic address: dieter.beyer@bayer.com.
Jazyk: angličtina
Zdroj: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2018 Mar; Vol. 47, pp. 147-155. Date of Electronic Publication: 2017 Nov 14.
DOI: 10.1016/j.tiv.2017.11.002
Abstrakt: Bisphenol A (BPA) is a high production volume compound. It is mainly used as a monomer to make polymers for various applications including food-contact materials. The primary route of exposure to BPA in the general population is through oral intake (EFSA 2015) however, other potential sources of exposure have also been identified, such as dermal contact. In the present study, the percutaneous absorption through human skin has been investigated in an in vitro study according to OECD TG 428 (Skin Absorption: In Vitro Method). In order to investigate potential dermal BPA metabolism during absorption, radiolabelled BPA was applied to fresh, metabolically competent, human skin samples (ring labelled 14 C BPA concentrations tested were 2.4, 12, 60 and 300mg/L). Measured as total radioactivity the mean absorbed dose (receptor compartment) ranged from 1.7-3.6% of the applied doses and the dermal delivery (epidermis+dermis+receptor compartment), sometimes also named bioavailable dose was 16-20% of the applied doses, with the majority of the radioactivity associated with epidermis compared to dermis and receptor fluid. No metabolism was observed in any of the epidermis samples; however some metabolism was observed in dermis and receptor fluid samples with formation of BPA-glucuronide and BPA-sulfate, and some polar metabolites.
(Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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