A Prospective Study of the Incidence of Juvenile-Onset Recurrent Respiratory Papillomatosis After Implementation of a National HPV Vaccination Program.

Autor:	Novakovic D; University of Sydney Medical School, University of Sydney and Kids Research Institute, Sydney Children's Hospitals Network (Westmead)., Cheng ATL; University of Sydney Medical School, University of Sydney and Kids Research Institute, Sydney Children's Hospitals Network (Westmead).; ENT Department, Children's Hospital Westmead, University of Sydney and Kids Research Institute, Sydney Children's Hospitals Network (Westmead)., Zurynski Y; University of Sydney Medical School, University of Sydney and Kids Research Institute, Sydney Children's Hospitals Network (Westmead).; Australian Paediatric Surveillance Unit, University of Sydney and Kids Research Institute, Sydney Children's Hospitals Network (Westmead)., Booy R; National Centre for Immunisation Research and Surveillance, Children's Hospital Westmead., Walker PJ; Otolaryngology Department, John Hunter Children's Hospital, Newcastle, New South Wales., Berkowitz R; Otolaryngology Department, Royal Children's Hospital, Melbourne, Victoria., Harrison H; ENT Department, Sydney Children's Hospital, Randwick, New South Wales., Black R; Paediatric Otolaryngology Head and Neck Surgery Department, Lady Cilento Children's Hospital, Brisbane, Queensland., Perry C; Paediatric Otolaryngology Head and Neck Surgery Department, Lady Cilento Children's Hospital, Brisbane, Queensland., Vijayasekaran S; Department of Otolaryngology - Head and Neck Surgery, Princess Margaret Hospital for Children, Perth, Western Australia., Wabnitz D; Department of Otolaryngology - Head and Neck Surgery, Women's and Children's Hospital, Adelaide, South Australia., Burns H; Paediatric Otolaryngology Head and Neck Surgery Department, Lady Cilento Children's Hospital, Brisbane, Queensland., Tabrizi SN; Royal Women's Hospital, Department of Microbiology and Infectious Diseases, and Murdoch Children's Research Institute, Infection and Immunity Theme, Parkville.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville., Garland SM; Royal Women's Hospital, Department of Microbiology and Infectious Diseases, and Murdoch Children's Research Institute, Infection and Immunity Theme, Parkville.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville., Elliott E; Australian Paediatric Surveillance Unit, University of Sydney and Kids Research Institute, Sydney Children's Hospitals Network (Westmead)., Brotherton JML; National HPV Vaccination Program Register, VCS, East Melbourne.; School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2018 Jan 04; Vol. 217 (2), pp. 208-212.
DOI:	10.1093/infdis/jix498
Abstrakt:	Background: Recurrent respiratory papillomatosis is a rare but morbid disease caused by human papillomavirus (HPV) types 6 and 11. Infection is preventable through HPV vaccination. Following an extensive quadrivalent HPV vaccination program (females 12-26 years in 2007-2009) in Australia, we established a method to monitor incidence and demographics of juvenile-onset recurrent respiratory papillomatosis (JORRP) cases. Methods: The Australian Paediatric Surveillance Unit undertakes surveillance of rare pediatric diseases by contacting practitioners monthly. We enrolled pediatric otorhinolaryngologists and offered HPV typing. We report findings for 5 years to end 2016. Results: The average annual incidence rate was 0.07 per 100000. The largest number of cases was reported in the first year, with decreasing annual frequency thereafter. Rates declined from 0.16 per 100000 in 2012 to 0.02 per 100000 in 2016 (P = .034). Among the 15 incident cases (60% male), no mothers were vaccinated prepregnancy, 20% had maternal history of genital warts, and 60% were first born; 13/15 were born vaginally. Genotyped cases were HPV-6 (n = 4) or HPV-11 (n = 3). Conclusion: To our knowledge, this is the first report internationally documenting decline in JORRP incidence in children following a quadrivalent HPV vaccination program. (© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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