Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons.

Autor:	Jackson JD; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114-2621, USA.; Harvard Medical School, Boston, MA 02115, USA., Rentz DM; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114-2621, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Neurology, Brigham and Women's Hospital-Center for Alzheimer Research and Treatment, Boston, MA, USA., Aghjayan SL; Department of Neurology, Brigham and Women's Hospital-Center for Alzheimer Research and Treatment, Boston, MA, USA., Buckley RF; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114-2621, USA.; Harvard Medical School, Boston, MA 02115, USA.; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Meneide TF; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114-2621, USA., Sperling RA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114-2621, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Neurology, Brigham and Women's Hospital-Center for Alzheimer Research and Treatment, Boston, MA, USA., Amariglio RE; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114-2621, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Neurology, Brigham and Women's Hospital-Center for Alzheimer Research and Treatment, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	Age and ageing [Age Ageing] 2017 Nov 01; Vol. 46 (6), pp. 988-993.
DOI:	10.1093/ageing/afx077
Abstrakt:	Objective: subjective cognitive concerns (SCC) have been proposed as a means of identifying individuals at risk for Alzheimer's disease (AD). However, the utility of SCCs has not been well-explored for African-Americans, who are twice as likely to develop AD dementia as Caucasians. We investigated whether race affects the association between SCCs and objective memory performance. Methods: we used a composite of three SCC questionnaires, and three challenging episodic memory tests. We studied 289 (61% female; African-American n = 47) clinically normal older individuals. Two hierarchical linear regressions assessed the modifying role of race on the association between SCC and objective memory performance. The first regression was conducted on the full sample, while the second matched the racial groups on age, estimated verbal IQ and socioeconomic status. Results: in the full sample, both groups reported similar levels of SCCs, P = 0.10, although African-Americans performed worse on the memory tasks, P < 0.001. No group differences were observed in the matched sample. The SCC × race interaction term was nonsignificant in the full sample, β = 0.109, P = 0.09, but was significant in the matched sample, β = 0.422, P = 0.037. While a significant correlation was observed between SCCs and memory among Caucasians, r = -0.401, the correlation was not found among African-Americans, r = -0.052. Conclusions: results suggest that the dissociation between SCCs and memory performance in African-Americans may indicate qualitative differences in how diverse groups endorse cognitive concerns, even after considering socioeconomic and educational factors. (© The Author 2017. Published by Oxford University Press on behalf of the British Geriatrics Society.All rights reserved. For permissions, please email: journals.permissions@oup.com)
Databáze:	MEDLINE
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