Surface modification of bulk titanium substrates for biomedical applications via low-temperature microwave hydrothermal oxidation.

Autor: Cheng A; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA.; Department of Biomedical Engineering, Emory University, Atlanta, GA.; Department of Biomedical Engineering, Peking University, Beijing Shi, China., Goodwin WB; School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA.; Department of Physics, Fisk University, Nashville, TN., deGlee BM; School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA., Gittens RA; Biodiversity and Drug Discovery Center, Institute for Scientific Research and High Technology Services (INDICASAT), Clayton, Panama., Vernon JP; Air Force Research Laboratory, OH., Hyzy SL; Department of Biomedical Engineering, Virginia Commonwealth University, VS., Schwartz Z; Department of Biomedical Engineering, Virginia Commonwealth University, VS.; Department of Periodontics, University of Texas Health Science Center at San Antonio, TX., Sandhage KH; School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA.; School of Materials Engineering, Purdue University, W. Lafayette, IN., Boyan BD; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA.; Department of Biomedical Engineering, Virginia Commonwealth University, VS.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2018 Mar; Vol. 106 (3), pp. 782-796. Date of Electronic Publication: 2017 Nov 27.
DOI: 10.1002/jbm.a.36280
Abstrakt: Micro-to-nanoscale surface topographies of orthopaedic and dental implants can affect fluid wetting and biological response. Nanoscale features can be superimposed on microscale roughness of titanium (Ti) surfaces at high temperatures, resulting in increased osteoblast differentiation. However, high temperatures can compromise mechanical properties of the bulk material. Here, we have developed a novel low-temperature microwave hydrothermal (MWHT) oxidation process for nanomodification of microrough (SLA) Ti surfaces. Nanoscale protuberances (20 -100 nm average diameter) were generated on SLA surfaces via MWHT treatment at 200°C in H 2 O, or in aqueous solutions of H 2 O 2 or NH 4 OH, for times ranging from 1 to 40 h. The size, shape, and crystalline content of the nanoprotuberances varied with the solution used and treatment time. The hydrophilicity of all MWHT-modified surfaces was dramatically enhanced. MG63 and normal human osteoblasts (NHOsts) were cultured on MWHT-treated SLA surfaces. While most responses to MWHT-modified surfaces were comparable to those seen on SLA controls, the MWHT-generated nanotopography reduced osteocalcin production by NHOst cells, suggesting that specific nanotopographic characteristics differentially mediate osteoblast phenotypic expression. MWHT processing provides a scalable, low-temperature route for tailoring nanoscale topographies on microroughened titanium implant surfaces with significantly enhanced wetting by water, without degrading the microscale surface structure of such implants. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 782-796, 2018.
(© 2017 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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