Deviant Behavior: Tick-Borne Pathogens and Inflammasome Signaling.
| Autor: | Shaw DK; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. dshaw@som.umaryland.edu., McClure EE; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. erin.mcclure@umaryland.edu., Wang X; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. xiwang@som.umaryland.edu., Pedra JHF; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. jpedra@som.umaryland.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Veterinary sciences [Vet Sci] 2016 Sep 28; Vol. 3 (4). Date of Electronic Publication: 2016 Sep 28. |
| DOI: | 10.3390/vetsci3040027 |
| Abstrakt: | In the face of an assault, host cells mount an immediate response orchestrated by innate immunity. Two of the best described innate immune signaling networks are the Toll- and the Nod-like receptor pathways. Extensive work has been done characterizing both signaling cascades with several recent advances on the forefront of inflammasome biology. In this review, we will discuss how more commonly-studied pathogens differ from tick-transmitted microbes in the context of Nod-like receptor signaling and inflammasome formation. Because pathogens transmitted by ticks have unique characteristics, we offer the opinion that these microbes can be used to uncover novel principles of Nod-like receptor biology. |
| Databáze: | MEDLINE |
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