A comprehensive review on biological properties of citrinin.

Autor: de Oliveira Filho JWG; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, Teresina, Piauí 64.049-550, Brazil., Islam MT; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil; Laboratory of Pharmaceutical Nanosystems - NANOSFAR, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil., Ali ES; Gaco Pharmaceuticals and Research Laboratory, Dhaka 1000, Bangladesh; School of Medicine, Flinders University, GPO Box 2100, Adelaide 5001, South Australia, Australia., Uddin SJ; Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh., Santos JVO; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil., de Alencar MVOB; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, Teresina, Piauí 64.049-550, Brazil; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil., Júnior ALG; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, Teresina, Piauí 64.049-550, Brazil; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil; Biomedicine Course, UNINOVAFAPI University Center, Teresina, Piauí, 64.073-505, Brazil., Paz MFCJ; Northeast Biotechnology Network (RENORBIO), Postgraduate Program in Biotechnology, Federal University of Piauí - IFPI, Teresina, Piauí 64.049-550, Brazil; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil., de Brito MDRM; Laboratory of Genetics and Toxicology-LAPGENIC, Post-Graduate Program in Pharmaceutical Science, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil., E Sousa JMC; Department of Biological Sciences, Federal University of Piauí, Picos, PI 64.600-000, Brazil., Shaw S; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., de Medeiros MDGF; Department of Biological Sciences, Federal University of Piauí, Picos, PI 64.600-000, Brazil., Dantas SMMM; Laboratory of Cytogenetics and Mutagenesis, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil., Rolim HML; Laboratory of Pharmaceutical Nanosystems - NANOSFAR, Post-Graduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí 64.049-550, Brazil., Ferreira PMP; Department of Biophysics and Physiology, Universidade Federal do Piauí, Teresina, Brazil., Kamal MA; King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, USA; Novel Global Community Educational Foundation, Australia., Pieczynska MD; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland., Das N; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria., Gupta VK; Department of Chemistry and Biotechnology, ERA Chair of Green Chemistry, School of Science, Tallinn University of Technology, 12618 Tallinn, Estonia., Mocan A; Department of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., Dos Santos Andrade TJA; NIAC-Nucleus of Research Applied to Sciences-IFMA-Federal Institute of Education, Science and Technology ofMaranhão (Campus São Raimundo das MAngabeiras), Brazil., Singh BN; Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow 226001, India., Mishra SK; Cancer Biology Laboratory, School of Biological Sciences (Zoology), Dr. Harisingh Gour Central University, Sagar 470003, M.P., India. Electronic address: siddhartha.km@gmail.com., Atanasov AG; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. Electronic address: atanas.atanasov@univie.ac.at., Melo-Cavalcante AAC; Department of Chemistry, Netaji Subhas Mahavidyalaya, Udaipur 799114, Gomati Tripura, India.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2017 Dec; Vol. 110, pp. 130-141. Date of Electronic Publication: 2017 Oct 07.
DOI: 10.1016/j.fct.2017.10.002
Abstrakt: Citrinin (CIT) is a mycotoxin which causes contamination in the food and is associated with different toxic effects. A web search on CIT has been conducted covering the timespan since 1946. The accumulated data indicate that CIT is produced by several fungal strains belonging to Penicillium, Aspergillus and Monascus genera, and is usually found together with another nephrotoxic mycotoxin, ochratoxin A. Although, it is evident that CIT exposure can exert toxic effects on the heart, liver, kidney, as well as reproductive system, the mechanism of CIT-induced toxicity remains largely elusive. It is still controversial what are the genotoxic and mutagenic effects of CIT. Until now, its toxic effect has been linked to the CIT-mediated oxidative stress and mitochondrial dysfunction in biological systems. However, the toxicity strongly depends on its concentration, route, frequency and time of exposure, as well as from the used test systems. Besides the toxic effects, CIT is also reported to possess a broad spectrum of bioactivities, including antibacterial, antifungal, and potential anticancer and neuro-protective effects in vitro. This systematic review presents the current state of CIT research with emphasis on its bioactivity profile.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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