| Autor: |
Péresse T; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France., Jézéquel G; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France., Allard PM; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , CMU-Rue Michel Servet 1, 1211 Geneva 11, Switzerland., Pham VC; Advanced Center for Bioorganic Chemistry of the Institute of Marine Biochemistry, Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet, 8404, Caugiay, Hanoi, Vietnam., Huong DTM; Advanced Center for Bioorganic Chemistry of the Institute of Marine Biochemistry, Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet, 8404, Caugiay, Hanoi, Vietnam., Blanchard F; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France., Bignon J; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France., Lévaique H; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France., Wolfender JL; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , CMU-Rue Michel Servet 1, 1211 Geneva 11, Switzerland., Litaudon M; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France., Roussi F; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France. |
| Abstrakt: |
With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated stilbenes, schweinfurthins K-Q (7-13), were isolated, along with vedelianin (1), schwenfurthins E-G (2-4), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 1-13 were evaluated against the human glioblastoma (U87) and lung (A549) cancer cell lines. |
