Tumor Volume Assessment in Low-Grade Gliomas: A Comparison of Preoperative Magnetic Resonance Imaging to Coregistered Intraoperative 3-Dimensional Ultrasound Recordings.

Autor:	Munkvold BKR; Department of Neuroscience, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Bø HK; Department of Circulation and Medical Imaging, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway., Jakola AS; Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway.; Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.; Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden., Reinertsen I; Norwegian National Advisory Unit for Ultrasound and Image Guided Therapy, St. Olavs University Hospital, Trondheim, Norway.; Department of Medical Technology, SINTEF, Trondheim, Norway., Berntsen EM; Department of Circulation and Medical Imaging, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Radiology and Nuclear Medicine, St. Olavs University Hospital, Trondheim, Norway., Unsgård G; Department of Neuroscience, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway.; Norwegian National Advisory Unit for Ultrasound and Image Guided Therapy, St. Olavs University Hospital, Trondheim, Norway., Torp SH; Department of Pathology and Medical Genetics, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, NTNU, Trondheim, Norway., Solheim O; Department of Neuroscience, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway.; Norwegian National Advisory Unit for Ultrasound and Image Guided Therapy, St. Olavs University Hospital, Trondheim, Norway.
Jazyk:	angličtina
Zdroj:	Neurosurgery [Neurosurgery] 2018 Aug 01; Vol. 83 (2), pp. 288-296.
DOI:	10.1093/neuros/nyx392
Abstrakt:	Background: Image guidance based on magnetic resonance imaging (MRI) and/or ultrasound (US) is widely used to aid decision making in glioma surgery, but tumor delineation based on these 2 modalities does not always correspond. Objective: To analyze volumes of diffuse low-grade gliomas (LGGs) based on preoperative 3-D FLAIR MRIs compared to intraoperative 3-D US image recordings to quantitatively assess potential discrepancies between the 2 imaging modalities. Methods: Twenty-three patients with supratentorial WHO grade II gliomas undergoing primary surgery guided by neuronavigation based on preoperative FLAIR MRI and navigated 3-D US were included. Manual volume segmentation was performed twice in 3-D Slicer version 4.0.0 to assess intrarater variabilities and compare modalities with regard to tumor volume. Factors possibly related to correspondence between MRI and US were also explored. Results: In 20 out of 23 patients (87%), the LGG tumor volume segmented from intraoperative US data was smaller than the tumor volume segmented from the preoperative 3-D FLAIR MRI. The median difference between MRI and US volumes was 7.4 mL (range: -4.9-58.7 mL, P < .001) with US LGG volumes corresponding to a median of 74% (range: 42%-183%) of the MRI LGG volumes. However, there was considerable intraobserver variability for US volumes. The correspondence between MRI and US data was higher for astrocytomas (92%). Conclusion: The tumor volumes of LGGs segmented from intraoperative US images were most often smaller than the tumor volumes segmented from preoperative MRIs. There was a much better match between the 2 modalities in astrocytomas.
Databáze:	MEDLINE
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