Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.

Autor: Alaghband Y; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., Kwapis JL; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, United States., López AJ; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., White AO; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., Aimiuwu OV; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., Al-Kachak A; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., Bodinayake KK; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., Oparaugo NC; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., Dang R; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, United States., Astarabadi M; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States., Matheos DP; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States., Wood MA; 301 Qureshey Research Lab, Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, United States; Center for the Neurobiology of Learning and Memory (CNLM), Irvine, CA 92697, United States; Irvine Center for Addiction Neuroscience (ICAN), University of California, Irvine, CA 92697, United States; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, United States. Electronic address: mwood@uci.edu.
Jazyk: angličtina
Zdroj: Neurobiology of learning and memory [Neurobiol Learn Mem] 2017 Nov; Vol. 145, pp. 94-104. Date of Electronic Publication: 2017 Sep 08.
DOI: 10.1016/j.nlm.2017.09.001
Abstrakt: Histone deacetylases (HDACs) are chromatin modifying enzymes that have been implicated as powerful negative regulators of memory processes. HDAC3has been shown to play a pivotal role in long-term memory for object location as well as the extinction of cocaine-associated memory, but it is unclear whether this function depends on the deacetylase domain of HDAC3. Here, we tested whether the deacetylase domain of HDAC3has a role in object location memory formation as well as the formation and extinction of cocaine-associated memories. Using a deacetylase-dead point mutant of HDAC3, we found that selectively blocking HDAC3 deacetylase activity in the dorsal hippocampus enhanced long-term memory for object location, but had no effect on the formation of cocaine-associated memory. When this same point mutant virus of HDAC3 was infused into the prelimbic cortex, it failed to affect cocaine-associated memory formation. With regards to extinction, impairing the HDAC3 deacetylase domain in the infralimbic cortex had no effect on extinction, but a facilitated extinction effect was observed when the point mutant virus was delivered to the dorsal hippocampus. These results suggest that the deacetylase domain of HDAC3 plays a selective role in specific brain regions underlying long-term memory formation of object location as well as cocaine-associated memory formation and extinction.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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