Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs.

Autor: Flahou B; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium., Rossi M; Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland., Bakker J; Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands., Langermans JA; Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands., Heuvelman E; Animal Science Department, Biomedical Primate Research Centre, Rijswijk, The Netherlands., Solnick JV; Departments of Medicine and Microbiology & Immunology, Center for Comparative Medicine, University of California, Davis, CA, USA., Martin ME; Department of Microbiology and Molecular Genetics, University of California, Davis, CA, USA., O'Rourke J; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Ngoan LD; Faculty of Animal Science, University of Agriculture & Forestry, Hue University, Hue City, Vietnam., Hoa NX; Faculty of Animal Science, University of Agriculture & Forestry, Hue University, Hue City, Vietnam., Nakamura M; School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan., Øverby A; School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan., Matsui H; Kitasato Institute for Life Sciences and Graduate School of Control Sciences, Kitasato University, Tokyo, Japan., Ota H; School of Health Sciences, Shinshu University School of Medicine, Nagano, Japan., Matsumoto T; Department of Laboratory Medicine, Shinshu University Hospital, Nagano, Japan., Foss DL; Zoetis, Kalamazoo, MI, USA., Kopta LA; Zoetis, Kalamazoo, MI, USA., Omotosho O; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Franciosini MP; Department of Veterinary Medicine, University of Perugia, Perugia, Italy., Casagrande Proietti P; Department of Veterinary Medicine, University of Perugia, Perugia, Italy., Guo A; The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Liu H; The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China., Borilova G; University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Meat Hygiene and Technology, Brno, Czech Republic., Bracarense AP; Laboratory of Animal Pathology, Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Londrina, Paraná, Brazil., Lindén SK; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden., De Bruyckere S; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium., Zhang G; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium., De Witte C; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium., Smet A; Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium., Pasmans F; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium., Ducatelle R; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium., Corander J; Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland.; Department of Biostatistics, University of Oslo, Oslo, Norway., Haesebrouck F; Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Jazyk: angličtina
Zdroj: The ISME journal [ISME J] 2018 Jan; Vol. 12 (1), pp. 77-86. Date of Electronic Publication: 2017 Sep 08.
DOI: 10.1038/ismej.2017.145
Abstrakt: Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.
Databáze: MEDLINE