Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage.

Autor:	Malikova MA; Department of Surgery, Boston University, Boston Medical Center, 88 East Newton Street, Collamore Building, Suite D507a, Boston, MA 02118, USA.; Department of Surgery, Boston University, Boston Medical Center, 88 East Newton Street, Collamore Building, Suite D507a, Boston, MA 02118, USA., Tkacz JN; Department of Radiology, Boston Medical Center, Boston University, Boston, MA 02118, USA.; Department of Radiology, Boston Medical Center, Boston University, Boston, MA 02118, USA., Slanetz PJ; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Guo CY; Department of Biostatistics, Boston University, Boston, MA 02118, USA.; Department of Biostatistics, Boston University, Boston, MA 02118, USA., Aakil A; Department of Radiology, Boston Medical Center, Boston University, Boston, MA 02118, USA.; Department of Radiology, Boston Medical Center, Boston University, Boston, MA 02118, USA., Jara H; Department of Radiology, Boston Medical Center, Boston University, Boston, MA 02118, USA.; Department of Radiology, Boston Medical Center, Boston University, Boston, MA 02118, USA.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2017 May 02; Vol. 3 (3), pp. FSO197. Date of Electronic Publication: 2017 May 02 (Print Publication: 2017).
DOI:	10.4155/fsoa-2016-0063
Abstrakt:	Aim: Early breast cancer detection is important for intervention and prognosis. Advances in treatment and outcome require diagnostic tools with highly positive predictive value. Purpose: To study the potential role of quantitative MRI (qMRI) using T1/T2 ratios to differentiate benign from malignant breast lesions. Methods: A cross-sectional study of 69 women with 69 known or suspicious breast lesions were scanned with mixed-turbo spin echo pulse sequence. Patients were grouped according to histopathological assessment of disease stage: untreated malignant tumor, treated malignancy and benign disease. Results & Discussion: Elevated T1/T2 means were observed for biopsy-proven malignant lesions and for malignant lesions treated prior to qMRI with chemotherapy and/or radiation, as compared with benign lesions. The qMRI-obtained T1/T2 ratios correlated with histopathology. Analysis revealed correlation between elevated T1/T2 ratio and disease stage. This could provide valuable complementary information on tissue properties as an additional diagnostic tool. Competing Interests: Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties. No writing assistance was utilized in the production of this manuscript.
Databáze:	MEDLINE
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