| Autor: |
Pedersen OH; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Centre of Hemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark., Larsen ML; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Centre of Haemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark., Kristensen SD; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Faculty of Health, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark., Hvas AM; Centre of Hemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.; Faculty of Health, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark., Grove EL; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.; Faculty of Health, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark. |
| Abstrakt: |
BACKGROUND Clopidogrel is commonly used in the prevention and treatment of cardiovascular events. However, despite clopidogrel treatment, some patients experience recurrent ischemic events. CASE REPORT We present the case of a 58-year-old man with polycythemia vera and concomitant thrombocytosis who suffered 6 episodes of cerebral infarctions and 1 myocardial infarction, despite treatment with clopidogrel. Following his last ischemic event, the antiplatelet therapy was intensified from initially clopidogrel monotherapy to dual antiplatelet therapy with aspirin 75 mg once daily and ticagrelor 90 mg twice daily. Since then, no cardiovascular event has been reported. CONCLUSIONS This case report illustrates that insufficient platelet inhibition with clopidogrel monotherapy in a patient with thrombocytosis may be associated with recurrent arterial thrombosis. The exact reasons for the insufficient platelet inhibition are not known, but a plausible explanation may be an accelerated platelet turnover reflected by an increased number of immature platelets in this patient. |
