Obstructive sleep apnea does not impair cardiorespiratory responses to progressive exercise performed until exhaustion in hypertensive elderly.

Autor: Barbosa BT; Laboratory of Physical Training Studies Applied to Health, Physical Education Department, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil.; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil., da Cruz Santos A; Laboratory of Physical Training Studies Applied to Health, Physical Education Department, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil.; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil.; Physical Education Departament, Federal University of Paraiba, João Pessoa, PB, Brazil., Frazão M; Lauro Wanderley University Hospital, João Pessoa, PB, Brazil., Petrucci TR; Lauro Wanderley University Hospital, João Pessoa, PB, Brazil., Cucato GG; Israelita Albert Einstein Hospital, São Paulo, SP, Brazil., Sarmento AO; Heart Institute (InCor), FMUSP, São Paulo, SP, Brazil., Freitas EDS; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil., de Lima AMJ; Animal Anatomy and Physiology Department, Universidade Federal Rural de Pernambuco, Recife, PE, Brazil., Brasileiro-Santos MDS; Laboratory of Physical Training Studies Applied to Health, Physical Education Department, Universidade Federal da Paraíba (UFPB), João Pessoa, PB, Brazil. sbrasileiro@pq.cnpq.br.; Associate Graduate Program in Physical Education UPE/UFPB, João Pessoa, Brazil. sbrasileiro@pq.cnpq.br.; Physical Education Departament, Federal University of Paraiba, João Pessoa, PB, Brazil. sbrasileiro@pq.cnpq.br.
Jazyk: angličtina
Zdroj: Sleep & breathing = Schlaf & Atmung [Sleep Breath] 2018 May; Vol. 22 (2), pp. 431-437. Date of Electronic Publication: 2017 Aug 24.
DOI: 10.1007/s11325-017-1557-7
Abstrakt: Background: Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity.
Methods: In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h; n = 15) and with OSA (OSA: AHI ≥ 15 events/h; n = 13). All subjects underwent CPET and polysomnographic assessments. After normality and homogeneity evaluations, independent t test and Pearson's correlation were performed. The significance level employed was p ≤ 0.05.
Results: Hypertensive elderly with OSA presented lower heart rate recovery (HRR) in the second minute (HRR 2 ) in relation to the No-OSA group. A negative correlation between AHI and ventilation (VE) (r = -0.63, p = 0.02) was found in polysomnography and CPET data comparisons, and oxygen saturation (O 2 S) levels significantly correlated with VE/VCO 2slope (r = 0.66, p = 0.01); in addition, OSA group presented a positive correlation between oxygen consumption and O 2 S (r = 0.60, p = 0.02), unlike the no-OSA group.
Conclusions: OSA does not affect the CPET variables in hypertensive elderly, but it attenuates the HRR 2 . The association between O 2 S during sleep with ventilatory responses probably occurs due to the adaptations in the oxygen transport system unleashed via mechanical respiratory feedback; thus, it has been identified that OSA compromises the oxygen supply in hypertensive elderly.
Databáze: MEDLINE
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