Better Indigenous Risk stratification for Cardiac Health study (BIRCH) protocol: rationale and design of a cross-sectional and prospective cohort study to identify novel cardiovascular risk indicators in Aboriginal Australian and Torres Strait Islander adults.

Autor: Rémond MGW; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia. marc.remond@baker.edu.au., Stewart S; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia., Carrington MJ; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia., Marwick TH; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Kingwell BA; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., Meikle P; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia., O'Brien D; The Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia., Marshall NS; The Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia.; Sydney Nursing School, The University of Sydney, Sydney, NSW, Australia., Maguire GP; Baker Heart and Diabetes Institute, PO Box 6492, Melbourne, VIC, 3004, Australia.
Jazyk: angličtina
Zdroj: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2017 Aug 23; Vol. 17 (1), pp. 228. Date of Electronic Publication: 2017 Aug 23.
DOI: 10.1186/s12872-017-0662-7
Abstrakt: Background: Of the estimated 10-11 year life expectancy gap between Indigenous (Aboriginal and Torres Strait Islander people) and non-Indigenous Australians, approximately one quarter is attributable to cardiovascular disease (CVD). Risk prediction of CVD is imperfect, but particularly limited for Indigenous Australians. The BIRCH (Better Indigenous Risk stratification for Cardiac Health) project aims to identify and assess existing and novel markers of early disease and risk in Indigenous Australians to optimise health outcomes in this disadvantaged population. It further aims to determine whether these markers are relevant in non-Indigenous Australians.
Methods/design: BIRCH is a cross-sectional and prospective cohort study of Indigenous and non-Indigenous Australian adults (≥ 18 years) living in remote, regional and urban locations. Participants will be assessed for CVD risk factors, left ventricular mass and strain via echocardiography, sleep disordered breathing and quality via home-based polysomnography or actigraphy respectively, and plasma lipidomic profiles via mass spectrometry. Outcome data will comprise CVD events and death over a period of five years.
Discussion: Results of BIRCH may increase understanding regarding the factors underlying the increased burden of CVD in Indigenous Australians in this setting. Further, it may identify novel markers of early disease and risk to inform the development of more accurate prediction equations. Better identification of at-risk individuals will promote more effective primary and secondary preventive initiatives to reduce Indigenous Australian health disadvantage.
Databáze: MEDLINE
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