[18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva.

Autor: Eekhoff EMW; Department of Internal Medicine Section Endocrinology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: emw.eekhoff@vumc.nl., Botman E; Department of Internal Medicine Section Endocrinology, VU University Medical Center, Amsterdam, The Netherlands., Coen Netelenbos J; Department of Internal Medicine Section Endocrinology, VU University Medical Center, Amsterdam, The Netherlands., de Graaf P; Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands., Bravenboer N; Department of Clinical Genetics and Bone Histomorphology, VU University Medical Center, Amsterdam, The Netherlands., Micha D; Department of Clinical Genetics and Bone Histomorphology, VU University Medical Center, Amsterdam, The Netherlands., Pals G; Department of Clinical Genetics and Bone Histomorphology, VU University Medical Center, Amsterdam, The Netherlands., de Vries TJ; Department Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands., Schoenmaker T; Department Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands., Hoebink M; Department of Internal Medicine Section Endocrinology, VU University Medical Center, Amsterdam, The Netherlands., Lammertsma AA; Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands., Raijmakers PGHM; Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Bone [Bone] 2018 Apr; Vol. 109, pp. 143-146. Date of Electronic Publication: 2017 Aug 18.
DOI: 10.1016/j.bone.2017.08.012
Abstrakt: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease with a progressive course characterized by episodically local flare-ups, which often but not always leads to heterotopic bone formation (HO). Recently, we showed that [18F]NaF PET/CT may be the first tool to monitor progression of a posttraumatic flare-up leading to new HO, which was demonstrated in a patient with FOP who underwent a maxillofacial surgery. This paper evaluates [18F]NaF PET/CT as a marker of FOP disease activity, comparing its use with other imaging modalities known in literature. In addition, the follow-up of a spontaneous flare-up in a 19-year old patient is presented showing high muscle [18F]NaF uptake in one defined part within the flare-up area after three weeks. During follow-up [18F]NaF PET /CT scan revealed newly formed heterotopic bone but only in this previously active [18F]NaF region. In conclusion, increased muscle [18F]NaF uptake may predict future HO development in FOP patients. At present [18F]NaF PET/CT appears to be a sensitive imaging modality to serve as a noninvasive marker for bone formation and to monitor disease activity during flare-ups in FOP.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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