| Autor: |
Stefanello TF; Grenoble Alpes University, CERMAV-CNRS, Grenoble, France. rachel.auzely@cermav.cnrs.fr., Couturaud B, Szarpak-Jankowska A, Fournier D, Louage B, Garcia FP, Nakamura CV, De Geest BG, Woisel P, van der Sanden B, Auzély-Velty R |
| Jazyk: |
angličtina |
| Zdroj: |
Nanoscale [Nanoscale] 2017 Aug 24; Vol. 9 (33), pp. 12150-12162. |
| DOI: |
10.1039/c7nr03964f |
| Abstrakt: |
Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the synthesis, characterization and biological perspectives of light- and thermoresponsive hyaluronic acid (HA)-based nanogels containing coumarin as the photocleavable group. Newly synthesized nanogels exhibited interesting features: formation by a temperature-triggered self-assembly process, successful incorporation of poorly water-soluble molecules, light-responsiveness as demonstrated by a significant shift in the critical aggregation temperature after light irradiation, efficient internalization by cancer cells overexpressing the CD44 receptor of HA, ability to circulate for a prolonged period of time in the bloodstream after intravenous injection in mice and considerable detection in tumor tissues. Our findings indicate that coumarin-containing HA-based nanogels may be promising delivery systems for anticancer chemotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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