| Autor: |
Sohrabi M; Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran., Gholami A; Department of Public Health, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.; Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran., Azar MH; Division of Gastroenterology, Department of Internal Medicine, Uremia University of Medical Sciences, Urmia, Iran., Yaghoobi M; Division of Gastroenterology, Department of Medicine, Faculty of Health Science, Mc Master University, Hamilton, Canada., Shahi MM; Department of Analytic Chemistry, Faculty of Basic Sciences, Tehran Islamic Azad University, North Branch, Tehran, Iran., Shirmardi S; Department of Analytic Chemistry, Faculty of Basic Sciences, Tehran Islamic Azad University, North Branch, Tehran, Iran., Nikkhah M; Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran., Kohi Z; Department of Analytic Chemistry, Faculty of Basic Sciences, Tehran Islamic Azad University, North Branch, Tehran, Iran., Salehpour D; Department of Analytic Chemistry, Faculty of Basic Sciences, Tehran Islamic Azad University, North Branch, Tehran, Iran., Khoonsari MR; Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran., Hemmasi G; Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran., Zamani F; Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran., Sohrabi M; Department of Analytic Chemistry, Faculty of Basic Sciences, Tehran Islamic Azad University, North Branch, Tehran, Iran. mralikhah@hotmail.com., Ajdarkosh H; Gastrointestinal and Liver Disease Research Center (GILDRC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. ajdarkosh1345@yahoo.com. |
| Abstrakt: |
Cases of colorectal cancer (CRC) have increased dramatically in Middle Eastern and other Asian countries. Many studies indicate an important role of environmental factors, including trace elements as an etiology of cancer. This study aims to assess the concentration of eight trace elements in cancerous and adjacent non-cancerous tissues in case of CRC. In a cross-sectional study, conducted between March 2015 and February 2016, zinc (Zn), chromium (Cr), manganese (Mn), tin (Sn), copper (Cu), aluminum (Al), lead (Pb), and iron (Fe) levels were evaluated among patients suffering from CRC. All the patients underwent a full colonoscopy. Multiple samples were taken from cancerous lesions and adjacent healthy tissues that kept a minimum distance of 10 cm from the lesions. These specimens were kept at -80 °C. The classic flame atomic absorption spectroscopy (FAAS) method was applied in this study. The mean age of the study population was 55.6 ± 12.8. The median of Zn, Cr, Cu, Al, and Pb in cancerous tissues was significantly higher than that of healthy tissues (P < 0.05). Nevertheless, the median of Mn, Sn, and Fe was significantly lower than that of non-cancerous tissues (P < 0.05). Between colon and rectal specimens, we did not find a difference between Cr and Al levels and Zn, Sn, and Cu levels in cancerous and healthy tissues, respectively. We revealed that gender and history of smoking may influence the level of some trace elements. We revealed that the levels of eight elements were significantly different for cancerous and healthy tissues. This may play a role in developing CRC. These findings reflect the importance of environmental pollution in this setting. |
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