Thalamic and cerebellar hypermetabolism and cortical hypometabolism during absence status epilepticus.
| Autor: | Shimogori K; Department of Neurology, Aizawa Hospital, Matsumoto, Japan., Doden T; Department of Neurology, Aizawa Hospital, Matsumoto, Japan., Oguchi K; Department of Radiology, Aizawa Hospital, Matsumoto, Japan., Hashimoto T; Center for Neurological Diseases, Aizawa Hospital, Matsumoto, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | BMJ case reports [BMJ Case Rep] 2017 Jul 28; Vol. 2017. Date of Electronic Publication: 2017 Jul 28. |
| DOI: | 10.1136/bcr-2017-220139 |
| Abstrakt: | We report on a 17-year-old girl with absence status epilepticus who developed recurrent motionless confusional state and continuous generalised 3-4 Hz rhythmic delta waves on electroencephalogram (EEG). The patient had no history of absence, myoclonus or generalised convulsion. Her seizure was resistant to a combination of antiepileptic drugs including carbamazepine. Ictal positron emission tomography using [ 18 F]fluorodeoxyglucose ([ 18 F]FDG-PET) revealed hypermetabolism of the bilateral thalamus and cerebellum and hypometabolism of the frontal, parietal and posterior cingulate cortices. We diagnosed her seizure as absence status and obtained remission by changing medication. The findings of ictal metabolic alteration in previous studies and in our case confirm the pathogenic importance of the thalamus in absence status and that associated cortical deactivation and cerebellar activation may be related to the generation or maintenance of epileptic EEG discharges. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.) |
| Databáze: | MEDLINE |
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