| Autor: |
Baldim JL; Chemistry Institute, Federal University of Alfenas (Unifal-MG), 37130-001 Alfenas, MG, Brazil.; Human and Natural Sciences Centre, Federal University of ABC (UFABC), 09210-580 Santo André, SP, Brazil., de Alcântara BGV; Chemistry Institute, Federal University of Alfenas (Unifal-MG), 37130-001 Alfenas, MG, Brazil., Domingos ODS; Chemistry Institute, Federal University of Alfenas (Unifal-MG), 37130-001 Alfenas, MG, Brazil., Soares MG; Chemistry Institute, Federal University of Alfenas (Unifal-MG), 37130-001 Alfenas, MG, Brazil., Caldas IS; Parasitology and Pathology Department, Federal University of Alfenas (Unifal-MG), 37130-000 Alfenas, MG, Brazil., Novaes RD; Department of Structural Biology, Federal University of Alfenas (Unifal-MG), 37130-000 Alfenas, MG, Brazil., Oliveira TB; Department of Pharmacy, Federal University of Sergipe (UFS-SE), 491000-000 São Cristóvão, SE, Brazil., Lago JHG; Human and Natural Sciences Centre, Federal University of ABC (UFABC), 09210-580 Santo André, SP, Brazil., Chagas-Paula DA; Chemistry Institute, Federal University of Alfenas (Unifal-MG), 37130-001 Alfenas, MG, Brazil. |
| Abstrakt: |
Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development of drug resistance. Thus, a series of 40 flavonoids were investigated with the purpose of correlating these properties via structure and activity analyses based on integrated networks and QSAR models. The classical groups for the antioxidant activity of flavonoids were combined in order to explain the influence of antioxidant and prooxidant activities on the antiparasitic properties. These analyses become useful for the development of efficient treatments for leishmaniasis and trypanosomiasis. Finally, the dual activity of flavonoids presenting both anti- and prooxidant activities revealed that the existence of a balance between these two features could be important to the development of adequate therapeutic strategies. |
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