New Evidence for Causal Central Mechanism of Hyperglycemia in Subarachnoid Hemorrhage Secondary to Ischemic Degenerative Disruption of Circuitry Among Insular Cortex, Nodose Ganglion, and Pancreas: Experimental Study.

Autor: Aydın MD; Department of Neurosurgery, Medical Faculty, Ataturk University, Erzurum, Turkey. Electronic address: nmda11@hotmail.com., Kanat A; Department of Neurosurgery, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey. Electronic address: ayhankanat@yahoo.com., Aydın N; Department of Psychiatry, Bakirkoy Mental Diseases Education Hospital, Istanbul, Turkey., Kantarci A; Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey., Ayvaz MA; Department of Gastroenterology, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey., Rakici H; Department of Gastroenterology, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey., Yolas C; Department of Neurosurgery, Erzurum Regional Research Training Hospital, Erzurum, Turkey., Kepoglu U; Department of Neurosurgery, Bahcesehir University Faculty of Medicine, Istanbul, Turkey., Demirci E; Department of Pathology, Medical Faculty, Ataturk University, Erzurum, Turkey.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2017 Oct; Vol. 106, pp. 570-577. Date of Electronic Publication: 2017 Jul 11.
DOI: 10.1016/j.wneu.2017.06.176
Abstrakt: Introduction: Although hyperglycemia is a serious complication of subarachnoid hemorrhage, its pathophysiologic mechanism based on neural circuitry has not been known.
Materials and Methods: Twenty-five rabbits were divided into 4 groups, with 5 in the control group. The SHAM and study groups received 1 mL saline and 1 mL autologous arterial blood into the sylvian cisterna, respectively. Blood glucose values (BGVs) of all animals were recorded 3 times weekly. After 2 weeks, animals were decapitated. BGVs, the number of normal and degenerated neuron densities (DNDs) of insular cortex (IC), and nodose ganglia, degenerated islands of Reil's surfaces values, were estimated by stereologically and analyzed statistically.
Results: The mean blood glucose values were measured as 101 ± 10 mg/dL in the control group (n = 5), 114 ± 11 mg/dL in the SHAM group (n = 5), and 137 ± 12 mg/dL in the subarachnoid hemorrhage (SAH) group (n = 15). The DND of the nodose ganglion was 10 ± 3/mm 3 in the control group, while it was 45 ± 7/mm 3 in the SHAM group and 1688 ± 191/mm 3 in the SAH group. The DND of the IC was 65 ± 12/mm 3 in the control group, 689 ± 112/mm 3 in the SHAM group, and 3709 ± 643/mm 3 in the SAH group. In addition, the proportion of degenerated surface areas in the islet of Langerhans was 0.3% in the control group, 6% in the SHAM group, and 28% in the SAH group.
Conclusion: There is an important linear relationship among the blood glucose levels, DND of the IC, and nodose ganglia and degenerated surface areas of IL following experimentally induced sylvian SAH.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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