Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi.

Autor:	Townsend EM; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Institute of Healthcare Policy and Practice, School of Health, Nursing and Midwifery, University of West of Scotland, Paisley, United Kingdom., Sherry L; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.; Institute of Healthcare Policy and Practice, School of Health, Nursing and Midwifery, University of West of Scotland, Paisley, United Kingdom., Kean R; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Hansom D; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Mackay WG; Institute of Healthcare Policy and Practice, School of Health, Nursing and Midwifery, University of West of Scotland, Paisley, United Kingdom., Williams C; Institute of Healthcare Policy and Practice, School of Health, Nursing and Midwifery, University of West of Scotland, Paisley, United Kingdom., Butcher J; Institute of Healthcare Policy and Practice, School of Health, Nursing and Midwifery, University of West of Scotland, Paisley, United Kingdom., Ramage G; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom gordon.ramage@glasgow.ac.uk.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2017 Aug 24; Vol. 61 (9). Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2017).
DOI:	10.1128/AAC.00672-17
Abstrakt:	Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition. (Copyright © 2017 American Society for Microbiology.)
Databáze:	MEDLINE
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