Structural and physico-chemical analysis of calcium/strontium substituted, near-invert phosphate based glasses for biomedical applications.
Autor: | Patel U; Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK., Moss RM; Department of Medical Physics and Biomedical Engineering, University College London, London, UK., Hossain KMZ; Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK., Kennedy AR; Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK., Barney ER; Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK., Ahmed I; Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK., Hannon AC; ISIS Facility, Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, UK. Electronic address: alex.hannon@stfc.ac.uk. |
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Jazyk: | angličtina |
Zdroj: | Acta biomaterialia [Acta Biomater] 2017 Sep 15; Vol. 60, pp. 109-127. Date of Electronic Publication: 2017 Jul 04. |
DOI: | 10.1016/j.actbio.2017.07.002 |
Abstrakt: | Neutron diffraction, 23 Na and 31 P NMR, and FTIR spectroscopy have been used to investigate the structural effects of substituting CaO with SrO in a 40P Statement of Significance: Phosphate based glasses are extremely well suited for the delivery of therapeutic ions in biomedical applications, and in particular strontium plays an important role in the treatment of osteoporosis. We show firstly that the substitution of strontium for calcium in bioactive phosphate glasses can be used to control the dissolution rate of the glass, and hence the rate at which therapeutic ions are delivered. We then go on to examine in detail the influence of Sr/Ca substitution on the atomic sites in the glass, using advanced structural probes, especially neutron diffraction. The environments of most cations in the glass are unaffected by the substitution, with the exception of Mg, which becomes more disordered. (Copyright © 2017 Acta Materialia Inc. All rights reserved.) |
Databáze: | MEDLINE |
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