| Autor: |
Fernandez O; Hospital Regional Universitario de Malaga, Malaga, Espana., Oterino A; Hospital Universitario Marques de Valdecilla, Santander, Espana., Oreja-Guevara C; Hospital Clinico San Carlos, 28040 Madrid, Espana., Prieto JM; Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, Espana., Mendibe-Bilbao MM; Hospital de Cruces, Baracaldo, Espana., Garcia-Merino JA; Hospital Universitario Puerta de Hierro-Majadahonda, 28035 Majadahonda, Espana., Ramio-Torrenta L; Hospital Universitari Dr. Josep Trueta, 17007 Girona, Espana., Ginestal R; Fundacion Jimenez Diaz, 28040 Madrid, Espana., Meca-Lallana JE; Hospital Universitario Virgen de la Arrixaca., Murcia, Espana., Romero-Pinel L; Hospital General Universitari de Bellvitge, 08907 L'Hospitalet de Llobregat, Espana., Munoz D; Hospital Alvaro Cunqueiro, Vigo, Espana., Oliva-Nacarino P; Hospital Universitario Central de Asturias, 33006 Oviedo, Espana., Calles-Hernandez MC; Hospital Universitari Son Espases, Palma de Mallorca, Espana., Izquierdo G; Hospital Universitario Virgen Macarena, 41003 Sevilla, Espana., Martinez-Gines ML; Hospital General Universitario Gregorio Maranon, Madrid, Espana., Saiz A; Hospital Clinic de Barcelona. Institut Clinic de Malalties del Sistema Nervios, 08036 Barcelona, Espana., Comabella M; Hospitals Vall d'Hebron, 08035 Barcelona, Espana., Casanova-Estruch B; Hospital La Fe, 46009 Valencia, Espana., Brieva L; Hospital Arnau de Vilanova, 25198 Lleida, Espana., Arroyo R; Hospital Quiron, Pozuelo de Alarcon, Espana., Rodriguez-Antiguedad A; Hospital Universitario de Cruces. Universidad del Pais Vasco, 48903 Baracaldo, Espana. |
| Abstrakt: |
For the ninth year in a row the Post-ECTRIMS Meeting has been held in Madrid (Spain) with the aim of presenting and discussing the hottest issues debated at the ECTRIMS Congress by renowned specialists in multiple sclerosis in our country. One outcome of this scientific activity, endorsed by the Spanish Neurology Society, is this review article, which is published in two parts. This second part reflects the current controversy over the management of multiple sclerosis, especially as regards the progressive forms and their differential diagnosis. The work presents the latest advances in remyelination, where the use of the micropillar technique in laboratory stands out, and in neuroprotection, which is reviewed through a study of the optic nerve. Anti-CD20 antibodies are a very promising development and we find ourselves before a new mechanism of action and therapeutic target in cells to which little attention has been paid to date. Another notable fact is the high correlation between the levels of neurofilaments in cerebrospinal fluid and in serum, which could make it possible to avoid the use of cerebrospinal fluid as a biological sample in future studies of biomarkers. The review also provides a preview of the advances in clinical research, which will converge in clinical practice in the future, thereby conditioning the steps that should be taken in the therapeutic management of multiple sclerosis. |
