Lung cancer samples preserved in liquid medium: One step beyond cytology.

Autor: Mariano VS; Barretos Cancer Hospital/Pio XII Foundation, Molecular Oncology Research Center, Brazil., Leal LF; Barretos Cancer Hospital/Pio XII Foundation, Molecular Oncology Research Center, Brazil., Pastrez PRA; Barretos Cancer Hospital/Pio XII Foundation, Molecular Oncology Research Center, Brazil., Silva EM; Barretos Cancer Hospital/Pio XII Foundation, Molecular Oncology Research Center, Brazil., Reis RM; Barretos Cancer Hospital/Pio XII Foundation, Molecular Oncology Research Center, Brazil.; Research Institute of Life and Health Sciences (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - Associated Laboratory to the Government of Portugal, Braga/Guimarães, Portugal., Longatto-Filho A; Barretos Cancer Hospital/Pio XII Foundation, Molecular Oncology Research Center, Brazil.; Research Institute of Life and Health Sciences (ICVS), University of Minho, Braga, Portugal.; ICVS/3B's - Associated Laboratory to the Government of Portugal, Braga/Guimarães, Portugal.; Medical Laboratory of Medical Investigation (LIM) 14, Department of Pathology, Faculty of Medicine, University of São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Diagnostic cytopathology [Diagn Cytopathol] 2017 Oct; Vol. 45 (10), pp. 915-921. Date of Electronic Publication: 2017 Jun 06.
DOI: 10.1002/dc.23743
Abstrakt: Lung cancer is one of the most common cancer types in men and women worldwide with a high mortality rate. World Health Organization (WHO) classification has accepted biopsy as the primary sample for lung cancer diagnosis, pathological classification and molecular testing for management of patients, yet, the use of alternative sampling procedures is highly encouraged. Bronchial cytological samples require a less invasive collection technique and may be suitable for pathological and molecular analysis and storage in liquid medium. Furthermore, the molecular analysis of bronchial cytological samples allows the detection of molecular biomarkers, which may be useful for the selection of molecular targeted therapies. Thus, the purpose of this review is to describe the usefulness of bronchial cytological samples preserved in liquid medium from lung cancer patients for pathological diagnosis and molecular investigation.
(© 2017 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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