| Autor: |
Knox PP; Faculty of Biology, Moscow State University, Moscow, 119234, Russia., Timofeev KN; Faculty of Biology, Moscow State University, Moscow, 119234, Russia., Gorokhov VV; Faculty of Biology, Moscow State University, Moscow, 119234, Russia. gorokhgiceron149@gmail.com., Seifullina NK; Faculty of Biology, Moscow State University, Moscow, 119234, Russia., Rubin AB; Faculty of Biology, Moscow State University, Moscow, 119234, Russia. |
| Abstrakt: |
The study of the effect of vasodilator, antiplatelet agent, and inhibitor P-glycoprotein dipyridamole (DIP) on the functioning of the transmembrane protein of the reaction center (RC) of Rb. sphaeroides showed that the activation of RC by constant light generates the DIP radical cation, which significantly affects the kinetics of recombination of charges divided between photoactive bacteriochlorophyll and quinone acceptors. Thus, the antioxidant properties of DIP may affect the functional activity of membrane proteins, and this apparently should be taken into account in the studies of the mechanisms of therapeutic action of this drug. |
