Stratified Platelet-to-lymphocyte Ratio: A Novel Target for Prognostic Prediction of Hepatocellular Carcinoma after Curative Liver Resection.
| Autor: | Huang GQ; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Renji School of Wenzhou Medical University, Wenzhou, China., Zheng JN; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; School of The First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China., Zou TT; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; School of The Second Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China., Chen YR; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; School of The First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China., Shi KQ; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China., Poucke SV; Department of Anesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Ziekenhuis Oost-Limburg, Genk, Belgium., Cheng Z; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; School of The First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China., Ruan LY; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; School of The First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China., Zheng MH; Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of clinical and translational hepatology [J Clin Transl Hepatol] 2017 Mar 28; Vol. 5 (1), pp. 35-42. Date of Electronic Publication: 2017 Feb 25. |
| DOI: | 10.14218/JCTH.2016.00035 |
| Abstrakt: | Background and Aims: Platelet-to-lymphocyte ratio (PLR) has been shown to predict prognosis of cancers. We aimed to evaluate the prognostic value of stratification of PLR in patients after curative liver resection (CLR) for hepatocellular carcinoma (HCC). Methods: A total of 1804 patients who underwent CLR for suspected HCC between January 2007 and January 2014 were screened for the study. All of the patients were categorized into equal tertiles according to the number of patients and the distribution of PLR. Prognostic significance was determined for overall survival (OS) and was assessed using Kaplan-Meier analysis. Univariate and multivariate Cox proportional hazard regression analyses were evaluated for association of all independent parameters with disease prognosis. Results: The optimal cut-off points of preoperative PLR were: (T1) 11.98-75.00, (T2) 75.00-113.33 and (T3) 113.33-567.50. There were obvious differences in each PLR tertile with mortality within 36 months of CLR ( p Competing Interests: The authors have no conflict of interests related to this publication. |
| Databáze: | MEDLINE |
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