A role for GABAergic interneuron diversity in circuit development and plasticity of the neonatal cerebral cortex.

Autor: Butt SJ; Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. Electronic address: simon.butt@dpag.ox.ac.uk., Stacey JA; Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK., Teramoto Y; Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK., Vagnoni C; Department of Physiology, Anatomy & Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.
Jazyk: angličtina
Zdroj: Current opinion in neurobiology [Curr Opin Neurobiol] 2017 Apr; Vol. 43, pp. 149-155. Date of Electronic Publication: 2017 Apr 08.
DOI: 10.1016/j.conb.2017.03.011
Abstrakt: GABAergic interneurons are a highly heterogeneous group of cells that are critical for the mature function and development of the neocortex. In terms of the latter, much attention has focused on the well-established role of parvalbumin (PV+)-expressing, fast spiking, basket cells in determining the critical period plasticity. However recent endeavours have started to shed the light on the contribution of other interneuron subtypes to early circuit formation and plasticity. Data suggests that there are significant interactions between PV+ cells and other interneuron subtypes that regulate circuit development in rodents in the first postnatal week. Moreover, a number of these early interactions are transient which points to an important, distinct role for interneuron diversity in setting up emergent neocortical processing.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: