Rituximab therapy in necrotizing autoimmune myopathy associated with anti-SRP antibody: A clinical case review.

Autor: Nóvoa Medina FJ; Servicio de Reumatología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España. Electronic address: fnovmed@hotmail.es., Gutiérrez Martínez J; Servicio de Neurología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España., González González Y; Servicio de Radiodiagnóstico, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España., Romero Díaz B; Servicio de Radiodiagnóstico, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España., Machín García S; Servicio de Reumatología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España., Rosas Romero A; Servicio de Reumatología, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, España.
Jazyk: English; Spanish; Castilian
Zdroj: Reumatologia clinica [Reumatol Clin (Engl Ed)] 2018 Nov - Dec; Vol. 14 (6), pp. 379-381. Date of Electronic Publication: 2017 Apr 25.
DOI: 10.1016/j.reuma.2017.02.009
Abstrakt: Necrotizing autoimmune myopathy (NAM) is a rare and emerging entity of idiopathic inflammatory myopathy (IIM). They have been associated with connective tissue disorders, viral infections, malignancy, anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase protein (with or without the use of statins). Anti-SRP associated NAM has different clinical and histological characteristics that differentiate them from other IIM, resulting in a poor prognosis. Very few cases treated with rituximab have been published, with varying clinical response. Here we describe a case of anti-SRP associated NAM refractory to conventional immunosuppressants and its successful long-term management with the combination of rituximab, corticosteroids and methotrexate.
(Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
Databáze: MEDLINE
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