Association of Glu298Asp Polymorphism of Endothelial NO Synthase Gene with Metabolic Syndrome Development: a Pilot Study.

Autor: Fattakhov NS; Immanuel Kant Baltic Federal University, Kaliningrad, Russia. nikola.fattahov@mail.ru.; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia. nikola.fattahov@mail.ru., Skuratovskaya DA; Immanuel Kant Baltic Federal University, Kaliningrad, Russia., Vasilenko MA; Immanuel Kant Baltic Federal University, Kaliningrad, Russia., Kirienkova EV; Immanuel Kant Baltic Federal University, Kaliningrad, Russia., Zatolokin PA; Regional Hospital of the Kaliningrad Region, Kaliningrad, Russia., Mironyuk NI; Regional Hospital of the Kaliningrad Region, Kaliningrad, Russia., Litvinova LS; Immanuel Kant Baltic Federal University, Kaliningrad, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Mar; Vol. 162 (5), pp. 615-618. Date of Electronic Publication: 2017 Mar 30.
DOI: 10.1007/s10517-017-3670-9
Abstrakt: We studied association of single nucleotide polymorphism Glu298Asp (rs1799983) of the NOS3 gene with the risk of metabolic syndrome in the Slavic population. Blood samples were obtained from 128 patients with metabolic syndrome and 100 healthy individuals. Polymorphism Glu298Asp of the NOS3 gene was genotyped by allele-specific PCR. Allele Asp (OR=1.95, 95%CI 1.29-2.95, p=0.007) and genotype Asp/Asp (OR=2.56, 95%CI 0.98-6.72, p=0.04) were associated with the risk of metabolic syndrome in Slavic population. Patients with metabolic syndrome carrying genotype Asp/Asp had higher serum endothelin-1 level in comparison with Glu/Asp and Glu/Glu carriers.
Databáze: MEDLINE
Externí odkaz: