Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial.

Autor:	Bertone AL; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Reisbig NA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Kilborne AH; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Kaido M; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Salmanzadeh N; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Lovasz R; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Sizemore JL; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Scheuermann L; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Kopp RJ; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Zekas LJ; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA., Brokken MT; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University , Columbus, OH , USA.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2017 Mar 10; Vol. 4, pp. 31. Date of Electronic Publication: 2017 Mar 10 (Print Publication: 2017).
DOI:	10.3389/fvets.2017.00031
Abstrakt:	Objective: To assess if injection of allogeneic dental pulp tissue particles would improve lameness in horses with naturally occurring osteoarthritis (OA) or soft tissue (ST) injury. Design: Prospective, randomized, blinded, and controlled clinical trial and client survey assessment. Animals: Forty lame client-owned horses. Procedures: Sterile dental pulp, recovered from otherwise healthy foals that perish during dystocia, was processed under good manufacturing processing to produce mechanically manipulated, unexpanded pulp tissue particles containing viable cells surrounded in extracellular matrix. Forty lame client-owned horses with confirmed OA ( n  = 20), or ST injury (desmitis or tendonitis) received a 2 mL intra-articular ( n  = 20 OA) or intra-lesional ( n  = 20) injection of control transport vehicle ( n  = 20) or 10 × 10 6 dental pulp tissue particles ( n  = 20). Acclimatized horses had baseline measurements performed and were then injected on day 0. Horses were treadmill exercised for 2 weeks, evaluated by clinical parameters, lameness score, edema (score and circumference), pain on flexion (OA) or pressure (ST), and clients' scores for pain and discomfort before and through 45 days after pulp injection. Twenty horses were available for >2.5-year follow-up. Results: Pulp-treated horses showed decrease in lameness compared to baseline ( P  < 0.009) or placebo controls ( P  < 0.013) for at least 2 weeks. Client assessments of comfort were improved between before and 45 days after pulp injection ( P  < 0.001). Clinical improvement with ST injury was significantly greater than OA ( P  < 0.001). At >2.5-year follow-up, at least 10 horses were in work. Conclusion and Clinical Relevance: Dental pulp tissue particles can be considered as a treatment option for equine lameness due to OA, desmitis, or tendonitis.
Databáze:	MEDLINE
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