Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial.

Autor:	Chiavaroli L; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Mirrahimi A; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Faculty of Health Sciences, School of Medicine, Queen's University, Kingston, Ontario, Canada., Ireland C; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Mitchell S; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Sahye-Pudaruth S; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Coveney J; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Olowoyeye O; Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Patel D; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., de Souza RJ; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Department of Health Research Methods, Evidence & Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada., Augustin LS; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; National Cancer Institute 'Fondazione G. Pascale', Naples, Italy., Bashyam B; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Pichika SC; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Blanco Mejia S; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Nishi SK; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada., Leiter LA; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada., Josse RG; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada., McKeown-Eyssen GE; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Moody AR; Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Kendall CW; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Sievenpiper JL; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada., Jenkins DJ; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2017 Mar 22; Vol. 7 (3), pp. e015026. Date of Electronic Publication: 2017 Mar 22.
DOI:	10.1136/bmjopen-2016-015026
Abstrakt:	Objective: To assess associations between dietary intake and carotid intima media thickness (CIMT) by carotid ultrasound (CUS), a surrogate marker of cardiovascular disease (CVD) risk, in those with type 2 diabetes. Design: Cross-sectional analysis of baseline data from 325 participants from three randomised controlled trials collected in the same way. Setting: Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada. Participants: 325 participants with type 2 diabetes, taking oral antidiabetic agents, with an HbA1c between 6.5% and 8.0% at screening, without a recent cardiovascular event. Main Outcome Measures: CIMT by CUS and associations with dietary intake from 7-day food records, as well as anthropometric measures and fasting serum samples. Results: CIMT was significantly inversely associated with dietary pulse intake (β=-0.019, p=0.009), available carbohydrate (β=-0.004, p=0.008), glycaemic load (β=-0.001, p=0.007) and starch (β=-0.126, p=0.010), and directly associated with total (β=0.004, p=0.028) and saturated (β=0.012, p=0.006) fat intake in multivariate regression models adjusted for age, smoking, previous CVD event, blood pressure medication, antidiabetic medication and ultrasonographer. Conclusions: Lower CIMT was significantly associated with greater consumption of dietary pulses and carbohydrates and lower total and saturated fat intake, suggesting a potential role for diet in CVD risk management in type 2 diabetes. Randomised controlled trials are anticipated to explore these associations further. Trial Registration Number: NCT01063374. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
Databáze:	MEDLINE
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